2016 Fiscal Year Final Research Report
In vivo analysis of longevity mechanism of transcription factor DAF-16/FOXO
| Project/Area Number |
26450500
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
DAITOKU Hiroaki 筑波大学, 生命領域学際研究センター, 講師 (30361314)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 転写因子 |
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| Outline of Final Research Achievements |
Since transcription factor DAF-16 is required for lifespan extension in various long-lived mutants of the nematode C. elegans, it has been considered as a longevity gene. However, these results are based on genetic analysis and it is unclear whether transcriptional activity of DAF-16 is actually increased in long-lived mutants. Here we established novel in vivo luc system in C. elegans and demonstrated that there is a positive correlation between lifespan extension and DAF-16 activity.
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| Free Research Field |
分子生物学
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