2016 Fiscal Year Final Research Report
Development of Chiral Ligand Based on Chirality Transfer
| Project/Area Number |
26460005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | The University of Tokushima (2016)
Kyoto University (2014-2015) |
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Principal Investigator |
Yamada Ken-ichi 徳島大学, 大学院医歯薬学研究部(薬学系), 教授 (00335184)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 不斉触媒 |
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| Outline of Final Research Achievements |
In this project, improvement of our NHC ligand was pursued. Although the installation of a pendent coordinating functionality near the carbene carbon was failed, introduction of electron-withdrawing groups at the remote positions was successful to improve the regio selectivity in the allylic substitution reaction. In addition, chiral guanidine catalyst was designed on the basis of the chair NHC ligand. The catalyst showed an excellent performance in the asymmetric addition reaction of diketones to nitro olefins.
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| Free Research Field |
不斉合成
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