2016 Fiscal Year Final Research Report
Direct intra- and intermolecular aldol reactions by catalytic discrimination of aldehydes
| Project/Area Number |
26460007
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
Furuta Takumi 京都大学, 化学研究所, 准教授 (30336656)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 交差アルドール反応 / 位置選択性 / 立体選択性 / 不斉触媒 / アニリン / 軸性不斉 |
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| Outline of Final Research Achievements |
Catalytic discrimination among similarly reactive functional groups is a key to realizing unique and efficient chemo- and regioselective transformations of multi-functionalized molecules; however, formidable challenges to such discrimination remain.
Upon developing axially chiral aniline-type acid base catlysts, catalytic discrimination among formyl groups bearing similar reactivity was achieved in the highly regio-, diastereo-, and enantioselective intramolecular cross-aldol reactions of enolizable aliphatic dials.
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| Free Research Field |
有機合成化学
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