Development of one-pot multistep reaction using reaction field and its application to synthetic chemistry

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460008
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Okayama University
• Principal Investigator: Sawada Daisuke 岡山大学, 医歯薬学総合研究科, 教授 (00338691)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 反応場 / 可溶性ポリマー / ワンポット反応

Outline of Final Research Achievements

For the development of versatile one-pot multistep synthesis, we utilized soluble polymer. In Mannich reaction, we studied solvents, substrates, polymers, and we were able to obtain the desired compound in good yield with aqueous media, using PEG-dimethyl ether as the best polymer. Then, various substrates, reagents were tested, and we found that the figure of reaction field remarkably differed by the order of addition of substrates and reagents. In addition, the difference of the figure apparently affected the reaction yield.

Free Research Field

有機合成化学