2016 Fiscal Year Final Research Report
Development of novel synthetic methods of nitrogen-containing compounds based on ene-type reactions of enamines and aza-enamines
| Project/Area Number |
26460010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
Sugiura Masaharu 熊本大学, 大学院生命科学研究部(薬), 准教授 (00376592)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | エン型反応 / エナミン / 含窒素化合物 / 立体選択的合成法 |
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| Outline of Final Research Achievements |
Enamines undergo ene-type reactions with N-sulfonylimines or a N-sulfonylisocyanate as electrophiles. Subsequent reduction with sodium cyanoborohydride affords N-sulfonyl-1,3-dimamines or 3-aminoamides stereoselectively. Overall stereochemistry differs from that of domino reaction between enamines, electrophiles, and trichlorosilane.
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| Free Research Field |
有機合成化学
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