Investigation of tandem reaction using advantage of the substitution effect of the unsaturated bond

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460025
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Hiroshima International University
• Principal Investigator: Yanada Reiko 広島国際大学, 薬学部, 教授 (80239821)
• Co-Investigator(Renkei-kenkyūsha): TAKEDA KEI 広島大学, 大学院医歯薬学総合研究科, 教授 (30135032)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 位置選択的 / プロパルギルアルコール / Meyer-Schuster転位 / 4-キノロン / タンデム反応 / インドール / hypervalent / arylation

Outline of Final Research Achievements

We succeeded in Bi(OTf)3-catalyzed tandem Meyer-Schuster rearrangement and 1,4-addition to the resulting vinyl ketone, regioselective iodoazidation of alkynes to form α,α-Diazidoketones, tandem reaction of enynyl acetate, copper-catalyzed tandem amide N-arylation and regioselective cyclization of 2-alkynylbenzamides, and regioselective arylative ring-closing reaction of 2-alkynylphenyl derivatives to form arylated benzoxazin-2-ones, benzoxazin-2-amines and 2,3-disubstituted indoles.

Free Research Field

医歯薬学