2016 Fiscal Year Final Research Report
Development of an efficient inhibitor of green-algal morphogenesis inducer
| Project/Area Number |
26460026
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KENMOKU Hiromichi 徳島文理大学, 生薬研究所, 准教授 (10399438)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 不斉合成 / 蛍光標識物質 / 防藻剤 / グリーンタイド |
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| Outline of Final Research Achievements |
Green tide is a common name for a phenomenon known as an algal bloom when it is caused by a few species of green microalgae and green algae such as Ulva pertusa. The bloom is usually found in coastal area to dye over green or yellowish green color. Because green tide causes damage to many coastal fisheries every year, we have attempted the synthesis of an effective inhibitor of green-algal morphogenesis inducer ‘Thallusin’ with the aim to prevent the occurrence of green tide. Thallsin, isolated from a marine bacterium, is the only known natural product induces formation of foliaceous morphology from the cellular state of green algae. On the basis of a structure-activity relationship study with Thallusin, we found out the competitive inhibitor at low concentrations. Moreover, we have established a synthetic pathway to the optical active inhibitor by utilizing enzymatic hydrolysis resolution. Asymmetric synthesis of the fluorescence-labeled inhibitor was also achieved.
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| Free Research Field |
合成化学
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