Creation of efficient artificial oxygen carriers based on the myoglobin exhibiting high-oxygen deliverbility.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460031
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: Chiba University
• Principal Investigator: Neya Saburo 千葉大学, 大学院薬学研究院, 教授 (10156169)
• Co-Investigator(Renkei-kenkyūsha): KAWAGUCHI Akira T. 東海大学, 医学部, 教授 (30195052)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 人工酸素運搬体 / ミオグロビン / 人工ヘム / コバルトイオン / 有機ナノチューブ / 鉄原子

Outline of Final Research Achievements

Artificial blood is free from the blood-type and infection disease, and stored in long period. In our research we attempted the preparation of a hemoglobin-like blood-substitute based on myoglobin which has been scarcely developed as the oxygen carrier. The main results of our research are as follows. First, we could reduce the high oxygen affinity of myoglobin using the skeletal modification of iron porphyrin. Second, the influence of metal substitution of central iron in porphyrin to cobalt was found very effective to lower the oxygen affinity of myoglobin. Third, we have developed the method to make complex of the artificial myoglobins with the organic nanotubes. In the series of experiments, we found the critical problems to be improved, and pointed out the method to improve the technical problems. These critical points include the solvent pH, ionic strength, and temperature of the incubation to prepare the sealed myoglobin.

Free Research Field

薬品物理化学