2016 Fiscal Year Final Research Report
Establishment of in silico pharmaceutical product design based on CAE simulation
| Project/Area Number |
26460047
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Hoshi University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | CAEシミュレーション / 有限要素法 / DPCモデル / 残留応力 / 錠剤 / 重要品質特性 / 引張強度 / 崩壊時間 |
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| Outline of Final Research Achievements |
Residual stress distributions of tablets were estimated by the computer-aided engineering (CAE) technique, and their effects on the critical quality attributes (CQA) of tablets were investigated. Powders or granules composed of pharmaceutical active ingredients and typical excipients were prepared, and their compression process was defined by the Drucker-Prager cap (DPC) model. The DPC parameters were fed into the analysis using the finite element method, and the residual stress distribution of tablets was estimated. As a result, CQA values such as the tensile strength and the disintegration time were well predicted by the remained stress distribution, suggesting capabilities of CAE simulation on the tablet manufacturing process.
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| Free Research Field |
製剤学
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