2016 Fiscal Year Final Research Report
Control of Crystal Polymorph Transition and Morphology Utilizing Cyclodextrin Complexation
| Project/Area Number |
26460054
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Sojo University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | シクロデキストリン / 結晶多形 / 包接複合体 |
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| Outline of Final Research Achievements |
In this study, we conducted the crystallization of prostaglandin E1 from its amorphous α- and β-cyclodextrin inclusion compounds and the stabilizations of their amorphous state of the drug and the chemical stability of the drug by a combination of α- and β-cyclodextrins. Further, X-ray structure analyses of crystals of the isosorbide/β-cyclodextrin complex was conducted to gain insight into polymorphism for cyclodextrin inclusion complexes. The β-CyD-appended polyacrylic acids were prepared to gain insight into crystallization of drugs in polymeric gels containing β-cyclodextrin.
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| Free Research Field |
医歯薬学
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