2016 Fiscal Year Final Research Report
Identifying the novel therapeutic targets by investigating the regulatory mechanism of transcription complex during the development of heart failure
| Project/Area Number |
26460071
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 心筋細胞肥大 / 心不全 / ＧＡＴＡ４ / ｐ３００ |
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| Outline of Final Research Achievements |
GATA4 forms a large complex with an intrinsic histone acetyltransferase, p300 and these factors are involved in transcriptional regulation during myocardial cell hypertrophy. Moreover, noble p300/GATA4 binding partners, PRMT5/MEP5 complex, SWI/SNF complex, NuRD complex, and N-CoR/SMRT complex form a functional complex with p300/GATA4 and suppress hypertrophic responses in cardiomyocytes and development of heart failure.
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| Free Research Field |
循環器
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