Regulation of cell death by epigenetics regulatory factors upregulated during the early stages of hepatocarcinogenesis

2017 Fiscal Year Final Research Report

• Project/Area Number: 26460072
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Nagoya City University
• Principal Investigator: Osada Shigehiro 名古屋市立大学, 大学院薬学研究科, 准教授 (40263305)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: エピジェネティクス / ヒストン / ヒストン修飾酵素 / アセチル化 / メチル化

Outline of Final Research Achievements

Malignant transformation is caused by epigenetic mutations, including histone modification, as well as DNA mutations. In this study, we observed the expression and the stability of arginine methyltransferase CARM1, upregulated during the early stages of hepatocarcinogenesis. In addition, we analyzed effects of histone deacetylase HAC9 on the interaction factors and expression levels of cell death-related genes. Furthermore, we investigated the role of histone acetyltransferase HBO1 and histone variants H2a.z in autophagy. Our findings reveal that some of histone modification enzymes upregulated during the early stages of hepatocarcinogenesis might be involved in regulation of cell death.

Free Research Field

生物系薬学