2016 Fiscal Year Final Research Report
The functional analyses of fad104, a novel regulator of osteoblast differentiation.
| Project/Area Number |
26460074
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Nagoya City University |
|---|
Principal Investigator |
Nishizuka Makoto 名古屋市立大学, 大学院薬学研究科, 講師 (00363953)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | FAD104 / 骨分化 / 脂肪細胞分化 / がん細胞 |
|---|
| Outline of Final Research Achievements |
In this study, we demonstrated that the amino acid region 161-277 of FAD104 is required for interaction with Smad1, a regulator of osteoblast differentiation. Furthermore, knockdown and overexpression experiments showed that FAD104 suppressed the invasion, metastasis and anchorage-independent growth of cancer cells. In addition, we demonstrated that the N-terminal region of FAD104 is essential for inhibiting STAT3 activity.
|
| Free Research Field |
分子生物学、生化学
|
