2017 Fiscal Year Final Research Report
A novel interaction of nucleoporin Nup88 with vimentin and its role in cancer malignancy.
| Project/Area Number |
26460087
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Sojo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
國安 明彦 崇城大学, 薬学部, 教授 (90241348)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | Nup88 / vimentin / cancer |
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| Outline of Final Research Achievements |
It has been unclear whether nucleoporin Nup88 overexpressing in tumor tissues promotes cancer malignancy such as cell motility. In this study, we characterized a novel interaction between Nup88 and vimentin intermediate filament protein and examined its involvement in cell motility. Nup88, but not other nucleoporins we tested, bound to vimentin specifically. In addition, Nup88 interacted with vimentin directly. The N-terminal 541 amino acid residues of Nup88 bound to the N-terminal 96 amino acid residues of vimentin molecule. This interaction affected the vimentin organization process. Nup88 overexpressed in cells promoted cell motility in the presence of vimentin. Nup88, thus, may contribute to cell motility through changing the organization of vimentin.
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| Free Research Field |
分子生物学、生化学
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