Molecular mechanism of local pH signal mediated by pH-regulating transporter NHE1

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460091
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Hisamitsu Takashi 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (50327946)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: Na/H交換輸送体 / カルシニューリン / 心肥大 / ｐH

Outline of Final Research Achievements

We have previously reported that activation of NHE1 was found to enhance the NFAT signaling via calcineurin (CaN) which directly interact with NHE1, leading to cardiomyocyte hypertrophy. In this study, we suggested that differences in binding affinity between CaN and NHE1 or NFAT are critical for the enhancement of NFAT signaling. Moreover, we showed that TRPC6 is a new member of NHE1/CaN complex, and found that overexpression of TRPC6 amplified the NHE1/CaN/NFAT signaling.

Free Research Field

細胞生理学