2016 Fiscal Year Final Research Report
Regulatory mechanism of inflammation and mitochondrial function by galactolipids and SM
| Project/Area Number |
26460093
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIDA Atsushi 千葉大学, 大学院薬学研究院, 教授 (80130029)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | スフィンゴ脂質 / セラミド / 大腸炎モデルマウス / カルジオリピン / ミトコンドリア |
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| Outline of Final Research Achievements |
Sphingolipids are components of cellular membranes and also act as extra- and intra-cellular signals. In the present study, I examined following problems such as roles of sphingolipids on alpha-cytosolic phospholipase A2 (cPLA2alpha) that regulates inflammatory responses, regulatory mechanisms of ceramide kinase (CerK), and roles of galactose-containing sphingolipids on these enzymes. I showed that 1) caldiolipin that mainly localizes in the mitochondria bind with and activates ceramide kinase directly, 2) a galactose-containing lipid, lactosylceramide, activated cPLA2alpha via NADPH oxidase-mediated formation of reactive oxygen species, 3) progression of experimental colitis was enhanced in CerK-knockout mice.
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| Free Research Field |
生化学的薬理学
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