The roles of Brorin, a novel secreted protein, in the regulation of feeding

2017 Fiscal Year Final Research Report

• Project/Area Number: 26460096
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pharmacology in pharmacy
• Research Institution: Kyoto University
• Principal Investigator: Miyake Ayumi 京都大学, 薬学研究科, 講師 (40346044)
• Research Collaborator: ITHO Nobuyuki 京都大学, 国際高等教育院, 教授 ; KONISHI Morichika 神戸薬科大学, 教授
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: Bmp / アンタゴニスト / 脳・神経 / 視床下部 / 神経分化

Outline of Final Research Achievements

Brorin were predominantly expressed in developing neural tissues. The loss of Brorin resulted in the activation of Bmp signaling in mice and zebrafish. brorin morphants exhibited defective development of the ventral domain in the forebrain. Furthermore, we demonstrated that Brorin inhibited Bmp signaling and played a critical role in the development of the ventral domain and specification of GABAergic interneurons and oligodendrocyte progenitors in the forebrain. It was also implicated in the suppression of astrocyte generation in the forebrain. In addition, brorin is essential for the appropriate expression of axon guidance molecules and has a role in the formation of forebrain commissural axons. The present results suggest that Brorin is a secreted Bmp antagonist predominantly expressed in developing neural tissues and that it plays multiple roles in the development of the forebrain.

Free Research Field

分子生物学