2016 Fiscal Year Final Research Report
Regulatory mechanisms of neurovascular coupling by retinal Muller cells and the application for development of anti-glaucoma drugs
| Project/Area Number |
26460103
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 血管生物学 / 網膜神経 / グリア細胞 / 網膜血管 |
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| Outline of Final Research Achievements |
This study aimed to clarify the regulatory mechanisms of neurovascular coupling by retinal Muller cells in the retina using a rat model of retinal degeneration induced by an intravitreal injection of NMDA. The results suggest that 1) activation of the ERK pathway in the Muller cells is involved in protective effects of mTOR inhibitors on neuronal and vascular cells in the retina and 2) dysfunction of Muller cells induces degeneration of neuronal and vascular cells at least in part through the disturbance of glutamate metabolism. These findings expand and update our understanding of the mechanisms of neuronal-glial-vascular interactions in the retina, leading to novel therapeutics and strategies for treating glaucoma.
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| Free Research Field |
医歯薬学
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