2016 Fiscal Year Final Research Report
Elucidation of the mechanism of suppressing pulmonary fibrosis by stress proteins and its application to IPF therapy
| Project/Area Number |
26460104
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Musashino University (2016)
Keio University (2014-2015) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ストレスタンパク質 / 肺線維症 / スクリーニング |
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| Outline of Final Research Achievements |
Idiopathic pulmonary fibrosis (IPF) is a progressive and devastating chronic lung condition with poor prognosis; mean length of survival from time of diagnosis is 2.8-4.2 years.Current agents for treatment of IPF, such as steroids and immunosuppressants, have not been found to improve prognosis.In this study, I identified stress proteins that suppress the onset and progression of IPF, and elucidated the molecular mechanism. I also proposed a new candidate for IPF therapy from a library of medicines already in clinical use. Furthermore, for drug-induced pulmonary fibrosis, we also constructed an animal model focusing on inflammation and examined the effect of stress proteins on the model.
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| Free Research Field |
薬理系薬学
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