2016 Fiscal Year Final Research Report
Protective effects of GR-103691-related compound on the stroke mouse model
| Project/Area Number |
26460106
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 脳梗塞 / GR103691 |
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| Outline of Final Research Achievements |
In the stroke mouse model induced by rose bengal injection and irradiation (IR) of middle cerebral artery, the ischemic volume of 24 h after IR by TTC staining enlarged from 1 h, however, the difference was not observed 72 h after. Latency to fall in rotor rod test decreased for 1 h and 24 h after ischemia, and recovered to a sham level 48 h after. In contrast, The spontaneous motor activities (locomotor and vertical activities) and neuropathy scores assessed by posture, tail suspension test and platform walk test were dramatically damaged 1 h after IR, and then slowly recovered. There is a significant difference in these index between sham and ischemic group even after 72 h. In addition, significant correlation between the ischemic volume and neuropathy score 72 h after IR was observed. Edaravone and a GR103691-related compound decreased ischemic volume and suppressed behavioral damage. These data suggests that a GR103691-related compound will be lead compound for treatment of stroke.
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| Free Research Field |
薬理学
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