2016 Fiscal Year Final Research Report
Investigation of molecular basis in diabetes-associated vascular endothelial dysfunction and sex differences under chronic inflammation
| Project/Area Number |
26460107
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Hoshi University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 糖尿病 / 高血圧 / 内皮機能 / 血管平滑筋 / 内皮由来因子 / セロトニン / 慢性炎症 / 性差 |
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| Outline of Final Research Achievements |
Endothelial dysfunction is a hallmark of the pathophysiology of diabetes and hypertension. Although there is a possibility to associate between endothelial dysfunction and chronic inflammation in these diseases, detailed mechanisms in difference among arteries, their disease stages, and sexes remain unclear. Major findings obtained in this study are as follows: increased 5-HT-induced contractions are seen in carotid arteries from type 2 diabetic GK rats, SHR and high insulin-treated arteries (vs. their corresponding controls) and such increased contractions were resulted in activated various kinase pathways; sex difference of 5-HT-induced carotid arterial contraction is seen in STZ-induced diabetic rats; time-course difference of vascular responses to ACh, Up4A, and PE in renal arteries from type 2 diabetic OLETF rats and associated with increased COX activities; and EDH-mediated relaxation is impaired in superior mesenteric arteries from female OLETF rats.
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| Free Research Field |
病態生理学
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