Involvement of group IVA phospholipase A2 in the development and progression of non-alcoholic steatohepatitis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460110
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pharmacology in pharmacy
• Research Institution: Kyoto Pharmaceutical University
• Principal Investigator: Akiba Satoshi 京都薬科大学, 薬学部, 教授 (70231826)
• Co-Investigator(Renkei-kenkyūsha): ISHIHARA Keiichi 京都薬科大学, 薬学部, 講師 (80340446) ; KAWASHITA Eri 京都薬科大学, 薬学部, 助教 (80509266)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 非アルコール性脂肪肝炎 / ホスホリパーゼA2 / マクロファージ / 炎症

Outline of Final Research Achievements

The present study investigated a possible involvement of group IVA phospholipase A2 (PLA2), an inflammatory enzyme, in the development of non-alcoholic steatohepatitis (NASH). The results showed that the development of NASH was suppressed in PLA2-knockout mice but not monocyte- or endothelial cell-specific conditional PLA2 knockout mice. A specific inhibitor of PLA2 ameliorated liver fibrosis in NASH model mice. The present results suggest that the development and progression of NASH is mediated by PLA2 probably in hepatocytes and/or hepatic stellate cells.

Free Research Field

病態生化学