2017 Fiscal Year Final Research Report
Physiological roles of endogenous hydrogen sulfide
| Project/Area Number |
26460115
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
Kimura Hideo 国立研究開発法人国立精神・神経医療研究センター, 神経研究所, その他 (30321889)
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| Co-Investigator(Renkei-kenkyūsha) |
HANAOKA Kenjiro 東京大学, 大学院薬学系研究科, 准教授 (70451854)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 硫化水素 / ポリサルファイド / シグナル分子 / TRPA1チャネル / ３MST |
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| Outline of Final Research Achievements |
Hydrogen sulfide is produced by enzymes and functions as a signaling molecule. Polysulfides, which have a higher number of sulfur atoms than hydrogen sulfide, were found to be produced by 3MST and transmit signals.Polysulfides activate TRPA1 channels, which are involved in the transmission of pain, by sulfurating two cysteine residues at the amino terminus of the channels. In the present study, we identified the producing pathways of polysulfides and the mechanism for the activation of TRPA1 channels. We also developped specific inhibitors of 3MST and a polysulfide specific fluorescence probe.
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| Free Research Field |
シグナル分子としての硫化水素とポリサルファイド
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