2016 Fiscal Year Final Research Report
Establishment of the disinfection technique applying photo-irradiation of polyphenols combined with polyphenol-induced wound healing effect based on structure-activity relationship analysis
| Project/Area Number |
26460116
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ポリフェノール / 光照射殺菌 / 創傷治癒 |
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| Outline of Final Research Achievements |
Short-term treatment with some polyphenols accelerated proliferation of fibroblasts. In addition, grape seed extract with a high content of catechin monomers and oligomers showed cytoprotective effect on fibroblasts exposed to various oxidative stressors. As octanol-water partition coefficient logP was thought to be a good indicator to predict such activity through affinity to cells, but no clear relationship between logP values and such biological activity was found. Of the polyphenols tested, some also showed bactericidal effect upon photoirradiation due to hydroxyl radicals generated possibly via photooxidation of their phenolic moieties. From these, it would be expected that some polyphenols could be agents possessing both disinfection and wound healing potentials.
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| Free Research Field |
医歯薬学
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