Search of the seeds of an antineoplastic drug and development of a lead compound which marine organism origin fungi produce

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460136
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Natural medicines
• Research Institution: Osaka University of Pharmaceutical Sciences
• Principal Investigator: Yamada Takeshi 大阪薬科大学, 薬学部, 准教授(移行) (20278592)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 海洋生物 / 真菌 / 細胞毒性物質 / 抗腫瘍性物質 / 海洋天然物

Outline of Final Research Achievements

We examined the metabolites produced the fungi separated from the various marine organization. A new compounds exhibiting potent cytotoxicity was isolated from an algae and a sea anemone, respectively, and we established the structures of new compounds. On the other hand, our continual examination about the cytotoxic substance production fungus led to find many new substances. In this study, we reaped rich harvest including the discovery of novel metabolites exhibiting significant biological activity, and the acquirement of the useful information for the stereochemistry.

Free Research Field

医歯薬学