2016 Fiscal Year Final Research Report
Study on the prenylflavonoids suppressing to advanced glycation end products, and preventing to diabetic complication.
| Project/Area Number |
26460141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Sojo University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 糖化終末化合物 / 糖尿病合併症 / プレニルフラボノイド / イカリソウ |
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| Outline of Final Research Achievements |
Because advanced glycation end products (AGEs) are reported that involved in the pathogenesis and progression of lifestyle-related diseases and aging diseases, treatment with AGEs inhibitors is believed to be a potential strategy for the prevention of these diseases. Accordingly, we have been searched for natural products that inhibits the formation of AGEs. In our previous study, MeOH extract of Epimedii Herba (EH) was found to inhibit the formation of AGEs during incubation of collagen-derived gelatin with ribose.
Epimedokoreanin B (EKB) which was typical prenylflavonoid from EH was found having most strong inhibitory activity among the tested samples. This result was able to demonstrate the potential of anti-glycation effect in EH in addition to the traditional tonic effect. Furthermore the development of foodstuff including EKB is expected as a supplement, tea or cosmetics with anti-glycation action.
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| Free Research Field |
天然薬物学
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