2016 Fiscal Year Final Research Report
Sterical structure and transformations of outer stimuli responsive N-alkyl pyridylamides
| Project/Area Number |
26460154
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Showa Pharmaceutical University |
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Principal Investigator |
Okamoto Iwao 昭和薬科大学, 薬学部, 教授 (80307074)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 立体構造変換 / 環境応答 |
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| Outline of Final Research Achievements |
We have designed a series of pyridyl amides as outer stimuli responsive molecules, especially acidity of surroundings. These amides have N-methyl amide functionality, which has characteristic cis-structure. According to these designs, we have synthesized linear type aromatic oligo amides, macrocyclic oligo amides, and N,N-diaryl type molecular switches.
We found that these novel amides showed sterical transformation according to change of acidity, and some of them showed dynamic transformation, which is different from change of small unit itself.
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| Free Research Field |
有機構造化学
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