2016 Fiscal Year Final Research Report
Antivirus drug development based on inhibition of N-glycan processing process
| Project/Area Number |
26460157
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Research Collaborator |
ARAI Shiori
UEMA Shun
ONDA Momoko
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 抗ウイルス / 糖鎖 / グルコシダーゼ / 阻害剤 |
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| Outline of Final Research Achievements |
An endoplasmic reticulum glucosidase II in host cells is a key target for the development of anti-virus agents aimed at the measure of virus outbreak. A disturbance of maturation of N-linked glycosylation of virus envelope proteins inhibited of the α-glucosidases have an influence on particle assembly and infectivity of the virus. Here we report on the identification of novel inhibitors of glucosidase II through a discovery of inhibitor screening from compound library and its biological evaluations, and anti-virus activity.
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| Free Research Field |
医薬品化学
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