2016 Fiscal Year Final Research Report
Design and synthesis of novel PCA-1 inhibitor for clinical anticancer drug
| Project/Area Number |
26460164
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Hyogo University of Health Sciences |
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Principal Investigator |
TANAKA AKITO 兵庫医療大学, 薬学部, 教授 (30454789)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUJIKAWA KAZUTAKE 大阪大学, 薬学研究科, 教授 (10207376)
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| Research Collaborator |
TOKORO MIYUKI (MABUCHI MIYUKI) 兵庫医療大学, 薬学部, 研究員 (60714897)
INOUE TAKASHI 大阪大学, 工学研究科, 教授 (20263204)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 抗がん剤 / PCA-1 |
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| Outline of Final Research Achievements |
We designed and synthesized novel PCA-1 inhibitors to obtain clinical effective novel anticancer drugs. Oral administration of HUHS015, a representative compound, showed the effectiveness in a DU145 Xenograft model withoutside effects, which demonstrated the effectiveness of PCA-1 inhibitor as anti-cancer drugs.
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| Free Research Field |
創薬
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