Toxicological effects by disposition of chemicals during development of Xenopus tropicalis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460171
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental and hygienic pharmacy
• Research Institution: Hiroshima University
• Principal Investigator: Sanoh Seigo 広島大学, 医歯薬保健学研究院(薬), 助教 (00552267)
• Co-Investigator(Renkei-kenkyūsha): KASHIWAGI KEIKO 広島大学, 両生類研究センター, 研究員 (00467763) ; HANADA HIDEKI 広島大学, 両生類研究センター, 助教 (50228508) ; SUZUKI KEN-ICHI 広島大学, 大学院理学研究科, 特任准教授 (90363043)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ネッタイツメガエル / 甲状腺ホルモン / 薬物代謝酵素 / アミオダロン

Outline of Final Research Achievements

Several clinical pharmaceuticals detected in the aquatic environment are concerned to result in unexpected effects on aquatic species. We found that amiodarone, anti-arrhythmic drug suppressed the metamorphosis of tadpoles controlled by the endogenous thyroid hormone. The antagonistic activity of amiodarone for thyroid hormone and its high accumulation in tadpoles could induce the toxicity. Furthermore, the levels of several drug-metabolizing enzyme expression changed during development of tadpoles, which could be partly caused by thyroid hormone. These are important findings to evaluate chemical accumulation and its related toxicity.

Free Research Field

衛生薬学