2016 Fiscal Year Final Research Report
Metallomic analysis to elucidate the metabolism and biological effects of arsenic compounds contained in Seafood
| Project/Area Number |
26460176
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ジメチルモノチオアルシン酸 / メタロミクス解析 / アルセノシュガー / 腸内細菌 / 代謝 / ジメチル亜ヒ酸 / グルタチオン / ジメチルメルカプトアルシン |
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| Outline of Final Research Achievements |
We have reported an analytical methods for arsenic compounds in seafood , among foodstuffs. In addition, we have focused on our attention to dimethylmonothioarsinic acid (DMMTA), which is known as an intermediate metabolite of arsenic compounds in seafood and an high toxic metabolite. Concerning cytotoxicity and toxic mechanism of DMMTA, we found that the toxicity of DMMTA deeply involved GSH and that clarified the possibility that multiple metabolites produced by GSH are involved in the mechanism. The results seem to be very useful for risk assessment of arsenic compounds derived from seafood.
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| Free Research Field |
環境毒性学
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