RXR agonists and tributyltin have the ability to induce white-to-brown fat conversion.

2017 Fiscal Year Final Research Report

• Project/Area Number: 26460184
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental and hygienic pharmacy
• Research Institution: National Institute of Health Sciences
• Principal Investigator: Nishimaki-Mogami Tomoko 国立医薬品食品衛生研究所, 生化学部, 主任研究官 (90174333)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: RXRアゴニスト / 白色脂肪組織 / 白色脂肪褐色化 / ベージュ細胞分化 / トリブチルスズ

Outline of Final Research Achievements

White adipose tissue (WAT) and brown adipose tissue (BAT) have distinct developmental origins and distinct functions of energy storage and heat production, respectively. We previously found that RXR agonist PA024 prevented high-fat diet-induced obesity and increased oxygen consumption in mice. In this study, we investigated the mechanism. We found that administration of PA024 to mice led to increases in brown fat-selective gene expression in WAT. PA024 was shown to have the ability to directly induce brown fat-gene expression in white preadipocytes. The same effect was also caused by other synthetic RXR agonists and tributyltin.

Free Research Field

生化学/衛生化学