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2017 Fiscal Year Final Research Report

Do patients taking tacrolimus need to undergo CYP3A5 genotyping along with blood concentration monitoring?

Research Project

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Project/Area Number 26460189
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical pharmacy
Research InstitutionAkita University

Principal Investigator

Niioka Takenori  秋田大学, 医学部, 講師 (20722276)

Co-Investigator(Renkei-kenkyūsha) MIURA Masatomo  秋田大学, 医学部, 教授 (30265194)
SATOH Shigeru  秋田大学, 医学部, 教授 (80187195)
TAKAHASHI Naoto  秋田大学, 医学部, 教授 (80344753)
Research Collaborator KAGAYA Hideaki  秋田大学, 病院, 主任
Project Period (FY) 2014-04-01 – 2018-03-31
Keywordsタクロリムス / CYP3A5遺伝子多型 / 薬物動態 / 腎移植 / 骨髄移植 / TDM
Outline of Final Research Achievements

Appropriate tacrolimus (FK) treatment requires higher doses in CYP3A5 expressors (CYP3A5*1/*1 + *1/*3) compared with CYP3A5 nonexpressors (CYP3A5*3/*3), with the former also demonstrating longer times to achieve target trough concentration levels. On the other hand, the concentration of FK in the blood increases significantly in CYP3A5 nonexpressors taking CYP3A inhibitors, such as triazole antifungal agents. Therefore, FK administration should be dose-adjusted based on CYP3A5 genotype prior to initial FK administration, or co-administered with a CYP3A5 inhibitor. Thus, information on the CYP3A5 genotype is useful for therapeutic drug monitoring of FK.

Free Research Field

臨床薬理学

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Published: 2019-03-29  

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