Quantitative prediction of drug removal by hemodialysis based on permeation clearance of hemodialyzer

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460191
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: The University of Tokyo
• Principal Investigator: YAMAMOTO Takehito 東京大学, 大学院薬学系研究科(薬学部), 講師 (00376469)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 薬物動態学 / 血液透析 / 投与設計 / クリアランス / 透析性 / 定量的予測

Outline of Final Research Achievements

This study aimed to construct the quantitative prediction methods of drug removal by hemodialysis (fd), especially focused on the permeation clearance of hemodialyzer (KoA). The predicted fd values, which were calculated by the prediction formula incorporating KoA, are in good concordance with the observed values. This result indicatse that the fd values are quantitatively predictable by evaluating the KoA values of drugs in in vitro study.
In the future studies, we planed to measure the KoA values by in vitro hemodialysis experiment, and determine the in vivo fd values by analyzing the serum specimens obtained from patients receiving hemodialysis to confirm the clinical applicability of our prediction method.

Free Research Field

臨床薬物動態学