Role of microRNA on the pharmacokinetics and pharmacodynamics of tacrolimus in inflammatory bowel disease

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460195
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Mie University
• Principal Investigator: IKEMURA Kenji 三重大学, 医学部附属病院, 助教 (70513935)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: マイクロRNA / 潰瘍性大腸炎 / P-糖タンパク質 / タクロリムス

Outline of Final Research Achievements

Our study demonstrates that oral absorption of tacrolimus (an immunosuppressant) was increased in dextran sodium sulfate (DSS)-induced ulcerative colitis rats, and this is attributable to decreased intestinal P-glycoprotein. In addition, the altered expression of miRNAs in the small intestine were observed in DSS-induced ulcerative colitis rats. MiRNAs regulate the expression and function of proteins regulating pharmacokinetics in intestinal epithelial cells. Therefore, miRNAs could be significant factors affecting inter- and intra- individual variations in the pharmacokinetics of tacrolimus.

Free Research Field

医療薬学