Development and validation of the cocktail study for the method in detection of drug-drug interactions

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460202
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: University of Shizuoka
• Principal Investigator: UCHIDA shinya 静岡県立大学, 薬学部, 准教授 (80372522)
• Co-Investigator(Renkei-kenkyūsha): TANAKA Shimako 浜松医科大学, 医学部, 准教授 (10559925)
• Research Collaborator: MIURA Tomoyasu ; SASANO Tomomi ; OZAWA Miki ; SHINOHARA Miki ; NOGAMI Yuzuki
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: カクテル試験 / 薬物相互作用 / シトクロムP450

Outline of Final Research Achievements

A “cocktail” approach, which involves simultaneous administration of multiple cytochrome P450 (CYP)-specific probes, concurrently detects the activity of multiple CYP enzymes. We developed and validated the cocktail study by comparing the results of drug-drug interaction from a cocktail study with that from single probe studies. Changes of area under curves of probe drugs in the cocktail study were similar to those in the singe-probe study, suggesting that cocktail approach can evaluate drug interactions. This approach is expected to serve as a convenient method for detecting potential drug-drug interactions.

Free Research Field

臨床薬物動態学