2016 Fiscal Year Final Research Report
Development and evaluation of drug carrier nanoparticles with liquid crystalline-phase.
| Project/Area Number |
26460224
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Toho University (2016)
University of Shizuoka (2014-2015) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 立方液晶相 |
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| Outline of Final Research Achievements |
Cubosomes are nanoparticles with inverse bicontinuous cubic liquid crystalline phase. We have shown that cubosome can enhance the apparent solubility of insoluble drugs and stabilize the drug that is liable to be hydrolyzed. We have also found that mono-glyceride additives further improved the solubilizing ability of cubosomes. These results suggest that cubosome would be a promising drug carrier especially for highly-insoluble drugs.
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| Free Research Field |
物理薬剤学
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