2016 Fiscal Year Final Research Report
Developmental mechanism and functional significance of physiological lymphovenous anastomosis.
| Project/Area Number |
26460253
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Kobe University |
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Principal Investigator |
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| Research Collaborator |
LIU Xinyi
OTOWA Yasunori
MUKAI Kenta
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | マウス / 遺伝子変異 / 発生 / 胎生期浮腫 / リンパ管 |
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| Outline of Final Research Achievements |
In this study, we analyzed the developmental mechanism and functional significance of physiological lymphovenous anastomosis, and whether lymphovenous anastomosis in peripheral tissues improves severe embryonic edema caused by the loss of physiological lymphovenous anastomosis. We found that the formation of physiological lymphovenous anastomosis is regulated by Aspp1, that it is essential for fetal development and survival, and that the abnormality caused by its loss is not improved by lymphovenous anastomosis in peripheral tissues. Although the novel guidance molecule Semaphorin 3G is dispensable for formation of physiological lymphovenous anastomosis, we found that it regulates lymphatic vascular distribution by providing repulsion signals to lymphatic endothelial cells via Nrp2/PlexinD1 receptor complex.
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| Free Research Field |
血管生物学
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