2016 Fiscal Year Final Research Report
influence of trisomy 21 on early neural differentiation
| Project/Area Number |
26460275
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 遺伝子発現モニター / 人工染色体 / 神経分化誘導 |
|---|
| Outline of Final Research Achievements |
Chromosomal abnormalities, such as Trisomy for human chromosome 21 (Down syndrome), are thought to be the most common cause of mental retardation. To gain insight into the underlying cellular pathogenesis, we made a new system to monitor differentiation process from forebrain neural precursor cells into interneurons and oligodendrocytes by using a human artificial chromosome vector.
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| Free Research Field |
染色体工学
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