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2017 Fiscal Year Final Research Report

The translation inhibitor Pdcd4 is involved in the induction of cell differentiation

Research Project

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Project/Area Number 26460276
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General anatomy (including histology/embryology)
Research InstitutionKumamoto University

Principal Investigator

Eto Ko  熊本大学, 大学院先端科学研究部(理), 准教授 (40359964)

Research Collaborator Ushio Ayako  
Yamada Satomi  
Anai Chikara  
Muraoka Akihiko  
Hashimoto Airi  
Takaki Syohei  
Ikeda Saki  
Kashima Rui  
Project Period (FY) 2014-04-01 – 2018-03-31
KeywordsCell differentiation / mRNA translation / Translation inhibitor / Neurogenesis / Myogenesis / Pdcd4
Outline of Final Research Achievements

Undifferentiated cells can not only self-replicate but also differentiate. During cell differentiation, the expression of genes specific for undifferentiated cells is suppressed and then that of genes specific for differentiated cells is promoted. The present study indicated that increased levels of Pdcd4, a translation inhibitor suppressing mRNA translation, caused decreased levels of genes expressing in undifferentiated cells, inducing cell differentiation. Thus, Pdcd4 may be a molecular switch for undifferentiated cells to convert from their self-replication state to their differentiation state.

Free Research Field

分子細胞生物学

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Published: 2019-03-29  

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