2016 Fiscal Year Final Research Report
The gating system of responses to light in the suprachiasmatic nucleus, the circadian center
| Project/Area Number |
26460284
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Kindai University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 視交叉上核 / ゲート機構 / 網膜 |
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| Outline of Final Research Achievements |
We investigated the mechanisms of gating system of responses to light in the suprachiasmatic nucleus (SCN), mammalian circadian center. We got several new findings. (1) In the rat, the circadian oscillator in the dorsomedial SCN (DMSCN) determines the phase of the gate, which regulate responses to photic signal in the ventrolateral SCN(VLSCN). Then the gating system also locates in the retinal ganglion cell layer. (2) In the mouse, the circadian oscillator in the shell region within SCN also determines the phase of the gate in the SCN. In addition, the retinal gating system resides in the intrinsically photosensitive retinal ganglion cells (ipRGCs).
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| Free Research Field |
医歯薬学
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