Roles of LPS, cytokine and peripheral CRF receptors on gastrointestinal function

2017 Fiscal Year Final Research Report

• Project/Area Number: 26460287
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General physiology
• Research Institution: Asahikawa Medical College
• Principal Investigator: Nozu Tsukasa 旭川医科大学, 医学部, 准教授 (30312367)
• Co-Investigator(Kenkyū-buntansha): 奥村 利勝 旭川医科大学, 医学部, 教授 (60281903)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 内臓知覚 / 消化管運動 / ストレス / CRF / 過敏性腸症候群

Outline of Final Research Achievements

Corticotropin-releasing factor (CRF) exerts the action via CRF receptor subtype 1 (CRF1) and subtype 2 (CRF2). We demonstrated that enhanced colonic contractility and visceral hypersensitivity induced by stress were CRF1-triggered responses, and CRF2 suppressed these ones. Moreover, the signal balance of CRF1 and CRF2 may determined these colonic functional changes. Therefore, we advocated the balance theory of CRF signaling. Incidentally, we also showed that visceral hypersensitivity induced by stress was mediated via LPS-cytokine system, and CRF also regulated the immune system to contribute to this altered visceral sensation. Moreover, this response followed the balance theory of CRF signaling.

Free Research Field

消化管機能