Exploring the mechanisms for neuronal migration and intercellular communication steered by ion channels in the embryonic brain

2017 Fiscal Year Final Research Report

• Project/Area Number: 26460293
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General physiology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Akita Tenpei 浜松医科大学, 医学部, 准教授 (00522202)
• Co-Investigator(Renkei-kenkyūsha): FUKUDA Atsuo 浜松医科大学, 医学部, 教授 (50254272)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: イオンチャネル / 胎生期 / 大脳皮質形成 / GABA / 細胞移動 / 移動誘導因子 / 移動忌避因子 / 細胞内カルシウムシグナリング

Outline of Final Research Achievements

To elucidate the mechanisms for neuronal migration and intercellular communication steered by ion channels in the embryonic brain, we investigated the mechanisms of ion channel activation induced by the action of guidance molecules that promote migration or repulsion of GABAergic interneuron precursors during development of the cerebral cortex in embryos. We found that potassium ion channels are suppressed and anion channels are activated during migration, and that the regulation of ion channels during both migration and repulsion might be mediated by the rises in intracellular calcium ion concentration.

Free Research Field

細胞生理学・神経生理学