Insulin action on vagal afferents and its regulation in feeding and metabolisms

2017 Fiscal Year Final Research Report

• Project/Area Number: 26460302
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General physiology
• Research Institution: Jichi Medical University
• Principal Investigator: Yusaku Iwasaki 自治医科大学, 医学部, 講師 (60528420)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 求心性迷走神経 / インスリン / GLP-1 / オキシトシン / グルカゴン / 摂食 / 糖代謝

Outline of Final Research Achievements

Vagal afferent nerves are one of visceral sensory nerves linking from the peripheral organ to the brain, and might regulate feeding and metabolisms. Some of postprandial hormones including pancreatic insulin and glucagon, intestinal GLP-1 (glucagon-like peptide-1) and pituitary oxytocin acted on the overlapping population of vagal afferent neurons (approximately 10%). Activation of vagal afferent subclass by the endogenous GLP-1 induced suppression of feeding and improving glucose tolerance. The present study demonstrates that the subclass of vagal afferent activated by postprandial hormones including insulin regulates feeding and glucose metabolism.

Free Research Field

生理学（脳・自律神経、摂食調節、代謝学）