2016 Fiscal Year Final Research Report
How does oxytocin participate in an onset of schizophrenia process?
| Project/Area Number |
26460304
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 統合失調症 / オキシトシン / シナプス / パッチクランプ法 |
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| Outline of Final Research Achievements |
Prefrontal cortex (PFC), ventral tegmental area (VTA), and amygdala (AMG) neurons participate in an onset of schizophrenia process. We recorded miniature- excitability and inhibitory postsynaptic currents (mEPSCs/mIPSCs) from these neurons by whole cell patch-clamp recording, and examined the effect of oxytocin (OXT) on the amplitude and the frequency of each PSCs. On the recordings from PFC neurons, only the frequency of mEPSCs was increased by the OXT treatment, but there were no effect both on the amplitude of mEPSCs and the mIPSCs. On the recordings from VTA and AMG neurons, only the frequency of mIPSCs was increased by the OXT treatment, but there were no effect both on the amplitude of mIPSCs and the mEPSCs.
It was suggested that the improvement effect of OXT on a negative and a positive symptom of schizophrenia was expected in this experiment.
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| Free Research Field |
神経生理学
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