2016 Fiscal Year Final Research Report
Research on anticancer drug target that regulate two types of cell death, necrosis and apoptosis
| Project/Area Number |
26460310
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
Sato Akira 東京理科大学, 薬学部薬学科, 講師 (40530663)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ネクローシス / アポトーシス / マイクロRNA / 細胞死制御因子 / プロテオミクス / 全エクソンシークエンス / がん分子標的 / 核酸化学 |
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| Outline of Final Research Achievements |
We aimed to find and characterize anticancer target(s) in regulators of cell death-mode, necrosis or apoptosis, by genomic and proteomic approach. (1) Extracellular leaked proteins in necrosis or apoptosis were detected by proteomic approach; (2) Gene mutations related cell-death switching were found by whole exon sequencing; (3) We investigated the anticancer effectiveness for the previously reported cell-death regulators, and identified a possible anticancer microRNA.
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| Free Research Field |
細胞死制御
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