2016 Fiscal Year Final Research Report
Neuronal remodeling after focal stroke induced by astrocyte stimulation
| Project/Area Number |
26460315
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Gunma University |
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Principal Investigator |
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| Research Collaborator |
AMANO Izuki
OBI Kisho
TOBITA Seiji
YOSHIHARA Toshitada
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 脳梗塞 / アストロサイト / ドパミン / アリピプラゾール / 神経回路再編成 |
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| Outline of Final Research Achievements |
In this study, we observed the role of astrocyte on remodeling for functional compensation in contralateral hemisphere of focal stroke. We found that dopamine is one of the strong candidate for contributing the functional remodeling/recovery after focal stroke. We also found that repetitive application of Aripiprazole, one of the partial agonist for dopamine receptor, enhances the remodeling of neuronal circuit in intact hemisphere after focal stroke. Since the Aripiprazole enhances the activity of astrocyte if it repetitively applied, our study suggested that application of aripiprazole enhances the neuronal remodeling after focal stroke via activation of dopaminergic systems.
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| Free Research Field |
神経生理学
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