2016 Fiscal Year Final Research Report
Neuroinfammation induced by systemic stress and plasmalogen
| Project/Area Number |
26460320
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | プラズマローゲン / オーファンG蛋白共役型受容体 / 海馬 / NF-κB / リポポリサッカライド / ショートヘアピンRNA / 水迷路学習 / 神経新生 |
|---|
| Outline of Final Research Achievements |
(1) We found that the plasmalogen (Pls)-induced activation of protein kinases was mediated by at least 5 orphan G-protein-coupled receptors (GPCRs), GPR1, GPR19, GPR21, GPR27 and GPR61 using knockdown and overexpression cells (PLoS ONE, 11: e0150846, 2016). (2) We found that inflammatory stimuli reduced Pls contents by downregulation of Pls synthesizing enzyme, GNPAT, through the NF-κB-mediated recruitment of c-Myc onto the GNPAT promoter in both murine and human cell lines. (J Neurosci, 37 (15): 4074-4092, 2017). (3) Knock down of GNPAT in the mouse hippocampus impaired spatial memory and decreased brain-derived neurotrophic factor (BDNF) expression. Pls-containing diet in mice increased hippocampal Pls, enhanced spatial memory with high expressions of phosphorylated (p-) Akt, p-CREB and BDNF along with enhanced hippocampal neurogenesis, spine formation, and long term potentiation. (in submission).
|
| Free Research Field |
神経生理学
|
