2016 Fiscal Year Final Research Report
The molecular mechanism of resilience: an association between prolactin releasing peptide and neurogenesis
| Project/Area Number |
26460321
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
|
|---|
| Research Institution | Jichi Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | ストレス / プロラクチン放出ペプチド / レジリエンス / 心的外傷後ストレス障害 |
|---|
| Outline of Final Research Achievements |
Social defeat stress activated prolactin releasing peptide (PrRP)-synthesizing neurons in the dorsomedial hypothalamic nucleus, caudal nucleus tractus solitarii and ventrolateral medulla. PrRP deficient mice were suggested to have a lower fear threshold. PrRP may prevent the development of post-traumatic stress disorder (PTSD).
|
| Free Research Field |
生理学
|
