Morphofunctional study on inputs of the environmental information, three dimensional interacition and life cycle, of a new system for reproductive regulation.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460323
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Nippon Medical School
• Principal Investigator: Hitoshi Ozawa 日本医科大学, 大学院医学研究科, 大学院教授 (60169290)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: Kisspeptin / NKB / dynorphin / kisspeptin receptor / immunohistochemistry / menopause / suckling stimuli / PCOS

Outline of Final Research Achievements

We investigated about the kisspeptin neurons, which is known as the center of reproductive regulation and integrate the several information in the brain to relay to the HPG axis. Actually, we clearly investigated 1) the subcellular localization of kisspepin, NKB, and dynorphin in the KNDy neuronos, which are coexpressed kisspepin, NKB, and dynorphin in the arcute nucleus by immunoelectron microscopy, 2) the interrelationship between the change of kisspetpin neurons and athe change of reproductive function with aging, 3) the mapping of kisspeptin receptor expression in the rat brain, and 4) the change of expression of kisspepin of certain kind of model animals suc as PCOS an/or hypothyroidism.

Free Research Field

神経解剖学、神経内分泌学